关键词: 药物成瘾, 神经认知, 神经影像, 分子遗传, 生物标记

Abstract:

Drug addiction as a chronic relapsing disease of brain represents a progressive model from occasional drug use to regular or habitual use and finally to compulsive drug use. It has been suggested that drug addiction could be associated with potential vulnerabilities in different individuals, which might occur during the developmental stages of addiction. From recent decades, emerging studies that focused on neurobiological biomarkers of addiction have largely promoted the identification of candidate susceptibility biomarkers in this field. In this review paper, we summarized the research related to investigations on the neurocognitive, neuroimaging (e.g., functional magnetic resonance imaging, event-related potentials) as well as molecular genetic aspects of probable susceptibility biomarkers implicated in drug addiction. It aimed to provide a more comprehensive sight of view for better understanding the mechanisms of addiction, based on an integral “genes-brain-mind-behavior” theoretical framework. The review would also expect to support further exploration on possible targets for clinical intervention trials with an in-depth retrospect of current evidence on neurobiological biomarkers in drug addiction.

Key words: drug addiction, neurocognitive, neuroimaging, molecular genetics, biomarkers